PS 02-25 EFFECT OF NITROGLYCERIN ADMINISTRATION ON CARDIO-ANKLE VASCULAR INDEX

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Abstract

Objective:

The purpose of this study is to evaluate the effect of nitroglycerin (NTG) administration on the stiffness of arteries from the origin of the aorta to the ankle by monitoring with cardio-ankle vascular index (CAVI).

Design and Method:

The subjects include Normal Control (n = 31) and CAD patients (n = 25). A single 0.3 mg of NTG was administered sublingually. CAVI and blood pressure were measured at every 5 minutes for 20 minutes.

Results:

After oral administration of nitroglycerin in normal control, CAVI decreased significantly at 5, 10, 15 and 20 minutes (6.5 ± 0.9 to 5.2 ± 0.9, 5.5 ± 0.9, 5.7 ± 0.9 and 6.1 ± 1.0) respectively. In CAD patients decreased significantly at 5, 10, 15 and 20 minutes (10.7 ± 1.7 to 9.8 ± 1.8, 9.8 ± 1.8, 10.0 ± 2.0 and 9.8 ± 1.4) respectively. In comparison with both groups, ΔCAVI did not change significantly.

Conclusions:

CAVI demonstrated that NTG administration decreased the stiffness of the arteries from the origin of the aorta to the ankle in both groups, and indicating that responsibility of arterial smooth muscle cell to nitric oxide (NO) was preserved in CAD patients.

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