To investigate the changes of serum uric acid (UA) and its clinical significance in hypertensive patients with atrial fibrillation (AF).Design and Method:
495 hypertensive patients were enrolled in this study, of them 61 patients were hyperpietics with AF. The patients with congestive heart failure, coronary artery disease, valvular heart disease, congenital heart disease, cardiomyopathy, diabetes, renal failure, inflammatory conditions, and those who were taking drugs that affect UA metabolism were excluded. Clinical, laboratory, and echocardiographic characteristics were recorded.Results:
The age, duration of hypertension, serum UA, serum creatinine, left atrial diameter (LAD), interventricular septum thickness (IVST), and left ventricular posterior wall thickness (LVPWT) were significantly higher in patients with AF than in those without AF(P < 0.05 or P < 0.01), the left ventricular ejection fraction (LVEF) and the estimated glomerular filtration(eGFR) were lower in patients with AF than in those without AF(P < 0.05). Multivariable logistic regression analysis showed that serum UA was independent predictors of AF.Conclusions:
Increased serum level of UA may be associated with the development of hypertensive patients with AF(OR: 0.986, 95%CI: 0.982∼0.991, P < 0.001). UA has been associated with inflammation and oxidative stress.