The objectives of this study are: 1) evaluating the relevance of the retrograde blood flow of aorta, carotid, and femoral artery with arterial stiffness, and 2) an increment of aortic stiffness by reducing diastolic retrograde diastolic blood flow(RDBF) results in the development and progression of atherosclerosis indirectly.Design and Method:
Our study is a cross-sectional, observational design including 200 patients; 100patients of normotensive; 100 of hypertensive.Results:
Unlike normotensive group, the brachial ankle pulse wave velocity (PWV) and RDBF of hypertensive group increased (p < 0.05). Furthermore, this increment of PWV is well correlated with the increase in the RDBF (Pearson correlation = 0.43, p = 0.02), these correlations were independent of age, sex, diastolic pressure, and artery diameter. Arteriosclerosis resulted by increasing stiffness, increasing augmentation, and reducing amplification.Conclusions:
The evaluation of retrograde blood flow can be simple and noninvasive prognostic indicator for early detection and primary prevention of atherosclerosis.