PS 02-85 Different Influences of Excessive Body Weight and Elevated Blood Pressure from Childhood on Left Ventricular Geometric Remodeling in Adulthood: Beijing Blood Pressure Cohort Study

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Abstract

Objective:

Obesity and hypertension are two well established predictors for left ventricular hypertrophy (LVH) in adults. We aimed to examine the long-term impact of excessive body weight and elevated blood pressure (BP) from childhood on LVH and LV geometric remodeling in adulthood.

Design and Method:

Data were obtained from a school-based prospective study, which consisted of 1256 adults aged 27–42 years who had 2–10 measurements of body mass index (BMI) and blood pressure from childhood in 1987. The total area under the growth curve (AUC) and incremental AUC from childhood to adulthood were calculated to characterize the cumulative risk burden and long-term trends of BMI and BP during the follow-up duration. In the final survey, four LV geometric patterns were defined based on the values of left ventricular mass index and relative wall thickness: normal geometry, concentric remodeling (CR), eccentric hypertrophy (EH), and concentric hypertrophy (CH).

Results:

In adulthood, the prevalence rates of CR, EH, and CH were 26.4%, 2.0%, and 2.5%, respectively. In childhood, SBP but not BMI was associated with adult CR (Odds Ratio [OR] =  1.06,95% confidence interval [CI]  = 0.93–1.18 for BMI;OR  = 1.26,95%  =  1.08–1.47 for SBP), whereas BMI but not SBP was associated with adult EH (OR = 3.53,95%CI = 2.09–5.98 for BMI;OR = 1.04,95% CI = 0.65–1.66 for SBP). Both BMI and SBP were significantly associated with adult CH, and BMI exhibited a stronger association (OR = 2.69,95% CI = 2.09–5.98 for BMI; OR = 1.64,95% CI = 1.07–2.51 for SBP). In addition, BMI and SBP in adulthood, as well as total AUC and incremental AUC, were all associated with risk of CR, EH, and CH, and BMI measures showed stronger associations with adult EH and CH compared to corresponding SBP measures.

Conclusions:

Excessive body weight and elevated BP from childhood have different influences on the development of LV geometric remodeling in adulthood.

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