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Mild Cognitive Impairment is the frequent sequela of patients with neurovascular and cardiovascular disorders, especially patients with Atrial Fibrillation. Coexistence of hypertension and MCI have the negative reflect on the ADL index and may lead to vascular dementia. The aim of the study is Comparison of comorbidity of MCI and Hypertension on development of cognitive decline after stroke and MI.192 (93/99) poststroke and post- MI patients with AF performed. Cognitive function and daily activity evaluated by MMSE, ADL Index, Hamilton Depression Rating Scale Cognitive function investigated by neuropsychological battery test and acute phase and after 3 months. Both neurological (after Stroke) and cardiovascular (after Miocardial Infarction) patients with atrial fibrillation were separately divided in III groups: I- MCI alone, II- Hypertension alone, III- MCI+Hypertension. Groups did not differ due to vascular risk-factors and demographic variables.From patients with MI - MCI and Hypertension alone was diagnosed in 56(56,5%) and 38(38,3%), but after Stroke in 42 (45,1%) and 76 (81,7%) cases respectively. Hypertension+MCI- were revealed after MI in 42 (42,2%) and postStroke in 68 (71,1%) cases. Comparison of both groups revealed that Hypertension +MCI and Hypertension alone have more frequently were in poststroke group as well as ADL Index and MMSE, but Depression alone 58 (58,5%) and Executive Dysfunction Syndrome alone 63(63.6%) more frequently as well their comorbidity (34/34,3%) in MI vs posstroke. (p < 0.05) and correlated with multiple lacunar silent damage radiologically.In AF-poststroke patients more demented and hypertensive (OR 9.90, P = 0.031)., but the AF-MI patients have more frequently have mild cognitive decline and depression (OR 8,9, P >0.001).