[PS 03-25] ELEVATED AMBULATORY SYSTOLIC-DIASTOLIC PRESSURE REGRESSION INDEX IS GENETICALLY DETERMINED IN PATIENTS WITH CORONARY HEART DISEASE

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Abstract

Objective:

The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ambulatory systolic-diastolic pressure regression index (ASDPRI) in patients with CAD confirmed by coronary angiography.

Design and method:

In the present study, 1345 subjects with CHD were included. There were significant differences in 24-hour and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. These polymorphisms were included in the analysis of covariance.

Results:

Two out of three gene polymorphisms (LPA and ADAMTS7) as well as sex, age, BMI and diabetes were significantly related to 24-hour ASDPRI. There were significant differences in nighttime ASDPRI dipping for the PPAB2B, WDR12 and ADAMTS7 polymorphisms. Analysis of covariance revealed a significant relationship between the PPAB2B and WDR12 polymorphisms, sex, diabetes and nighttime ASDPRI dipping.

Conclusions:

In the present study, ADAMTS7 and LPA polymorphisms are related to 24-hour ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping.

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