The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ambulatory systolic-diastolic pressure regression index (ASDPRI) in patients with CAD confirmed by coronary angiography.Design and method:
In the present study, 1345 subjects with CHD were included. There were significant differences in 24-hour and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. These polymorphisms were included in the analysis of covariance.Results:
Two out of three gene polymorphisms (LPA and ADAMTS7) as well as sex, age, BMI and diabetes were significantly related to 24-hour ASDPRI. There were significant differences in nighttime ASDPRI dipping for the PPAB2B, WDR12 and ADAMTS7 polymorphisms. Analysis of covariance revealed a significant relationship between the PPAB2B and WDR12 polymorphisms, sex, diabetes and nighttime ASDPRI dipping.Conclusions:
In the present study, ADAMTS7 and LPA polymorphisms are related to 24-hour ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping.