PS 04-22 CHANGES OF ACE2/MAS EXPRESSION WITH CARDIAC REMODELING IN HYPERTENSIVE RATS

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Abstract

Objective:

The recent discovery of the new components of the renin-angiotensin system (RAS) suggests the importance of the maintenance of cardiovascular structure and functions. To assess the role of the ACE2-Mas axis in the regulation of cardiac structure and function, the present work investigated the expression of ACE2 and Mas receptor in the heart with cardiac remodelling that occurs in aortic constricted rats.

Design and Method:

Partial abdominal aortic ligation was carried out in Sprague-Dawley rats. Angiotensin AT1 receptor blockade and ACE inhibition were achieved by losartan and enalapril treatment, respectively.

Results:

Results showed that aortic constriction increased left ventricular hypertrophy, fibrosis, MAP, plasma renin activity (PRA) and cardiac ACE levels, but decreased the expression of cardiac ACE2 and Mas receptor. Losartan treatment significantly decreased MAP, left ventricle hypertrophy (LVH), fibrosis, and increased cardiac ACE2 and Mas expression. Enalapril also improved the cardiac parameters with a rise in cardiac ACE2, but did not change the Mas level.

Conclusions:

Aortic constriction results in cardiac hypertrophy, fibrosis and a rise of cardiac ACE expression. Both AT1 receptor blocker and ACE inhibitor play a cardioprotective role in aortic constriction. However, AT1 receptor blocker particularly promotes cardiac ACE2 and Mas receptor levels. ACE inhibitor is associated with the inhibition of ACE and normalization of cardiac ACE2 activity.

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