PS 05-14 B-ADRENOREACTIVITY AND HOME BLOOD PRESSURE ARE PREDICTORS FOR EFFICIENCY OF RENAL DENERVATION

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Abstract

Objective:

The objective of this research was to study predictors’ effective dynamics of parameters self-home blood pressure (SHomeBP) and β-adrenoreactivity (β-AR) after renal sympathetic denervation (RSD).

Design and Method:

All participants (P.) of research have given the informed agreement. We used Home BP-protocol from Guidelines for BP Measurements ESH/ESC used initially (i.) and after (a.) RSD during 4 and 24weeks (w). RSD BP should be used at least thrice in the morning between 06–10h. Measures of BP were self-reported by the participants on a booklet and into the automated memory of 29 patients with essentially hypertensive (BP > 160/100 mmHg despite three or more antihypertensive drugs), age - 52.4 ± 9.9 old years. We used the method that evaluates inhibition of erythrocyte hemolysis placed in hypo-osmotic environment in the presence of β-blockers - 1- (1izopropilamino) -3- (1-naphthalenyl-oxy) -2-propanol hydrochloride, which binds to β-AR erythrocyte membranes, reduces the degree of hemolysis for the β-AR in conventional units (CU). RSD was done bilaterally using transfemoral access (8 ablation points, temperature control mode, target t = 60°C, power limit = 8 watt, duration = 2 min). The patients were instructed to maintain pharmacotherapy unchanged during the study.

Results:

All patients were divided into 3 groups (g) in i.: 1g had SBP > 170 mmHg and AR > 40 conventional units (CU), 2g - SAD < 170 mmHg and AR < 40CU, 3g - SAD > 170 mmHg and AR < 40CU. The results are shown in the table 1.

Conclusions:

Total score baseline SBP and β-AR helps determine the effectiveness of RSD in order to reduce BP. The method needs further study.

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