PS 05-20 АORTIC STIFFNESS IN EUROPEAN ETHNICITY PERSONS WITH ARTERIAL HYPERTENSION RELATED TO SMOKING

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Abstract

Objective:

To evaluate aortic stiffness features in European and Asian ethnicity individuals with arterial hypertension (AG) according to the known risk factors, such as smoking.

Design and method:

The first part of our research concluded about 93 Slavic ethnicity people (59,4 ± 2,85 years old): 1-st group - practically healthy people (subgroup 1А – nonsmoking (34 persons, control), subgroup 1B - smoking (29 persons); 2-nd group - patients with АG: subgroup 2А nonsmoking (37 persons) and subgroup 2B smoking (23 persons). Aortic pulse wave velocity (APWV), augmentation index (АI), systolic and diastolic coronary perfusion index area ratio (SAI/DAI) were determined through the non-invasive arteriography (Arteriograph TensioClinic TL1 (TensioMed, Hungary)).

Results:

Compared with control group APWV (6,2 1,2 м/s) was significant increased in smoking Slavs with AG (9,68 1,3 м/s, р < 0,01), in nonsmoking persons with AG (9,09 ± 1,6 м/s, р < 0,01) and in smoking persons without Ag (9,56 ± 1,5 м/s, р < 0,01). Wherein it was observed nothing significant difference between APWV between subgroups 2B, 2A, 1B. Unlike APWV, AI was at optimal values in smoking, non-smoking persons without AG (−40,9 ± 12,1 and −41,6 ± 12,2, р > 0,05). In average AI was not exceed of normal values in subgroups 2B and 2A (−20,5 ± 6,0 and −22,9 ± 9,6, р > 0,05). Significant difference was observed between AI in group 1 and 2 (р < 0,01). SAI/DAI ratio evaluation was not show any significant differences in examined subgroups (р > 0,05).

Conclusions:

We have found aortic stiffness increase in the Slavic ethnicity people, related with the presence of such risks factors as АG and smoking and characterized primarily by the APWV increasing. Observed features of аrterial stiffness in accordance with AI allow to talk that persons with AG are in the peripheral vascular bed stress state and probably the persons without AG have a compensatory peripheral vasodilatation. These are the preliminary results, further researches in this direction are needed.

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