PS 05-21 IN HYPERTONIC PATIENTS GLYCATED HGBA1C COULD BE ALSO A PREDICTOR OF ATHEROTHROMBOSIS INFLUENCED BY HDL LEVEL

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Abstract

Objective:

Non adequately regulated glycemic level in patients with known hypertension, expressed in % HgbA1C, cause disbalance in lipid metabolism. Very important antiatherogenic role in this process has the reversal transport of lipid particles from the artery walls itself towards liver, though regulated by HDL cholesterol. It stimulates the genesis of NO and vasodilatation, thus having anthitombogenic effect. In almost 2/3 of coronary patients the level of HDL is decreased. As a result cardiovascular complications can be seen, especially in those having diabetes and hypertension.

Design and Method:

Assessment if there is any link between high levels of glycosylated HgbA1C on the HDL level in cardiovascular, hypertonic patients with diabetes mellitus.

Design and Method:

We have been studded interaction between linkage of HgbA1C and HDL cholesterol, and also their influence to cardiovascular events in the group of 20 patients with proven coronary disease (on coronarography 2 or more diameter stenosis over 50%) and having both hypertension and diabetes mellitus.

Results:

There is exponential correlation between unregulated glycaemia and values of HDL. The mean values of HgbA1C (7–8,5%), while for HDL (0,9–1,5), pointing out that is the high risk population with non-adequately regulated glycaemia. But, although having in mind this is very small sample, all cardiovascular events were not significantly increased (HR 0,86–2,31; p-0,083)

Conclusions:

HgbA1C is not only biomarker of non-regulated glycaemia for a longer period but could be a possible predictor of lipid profile in cardiovascular patients having hypertension and diabetes mellitus.

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