PS 05-22 INDIVIDUALIZED HYPERTENSION PREVENTION AND TREATMENT BASED ON TRADITIONAL CHINESE MEDICINE CONSTITUTION THEORY: A LARGE COMMUNITY-BASED STUDY AMONG CHINESE RESIDENTS

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Abstract

Objective:

Fundamental theory of traditional Chinese medicine constitution (TCMC) emphasizes that those with specified TCMC are more likely to suffer from specified disease as well as treatment strategies may be prescribed to those with different TCMC, even if suffering from the same disease. However, little has known whether some TCMCs are easier to result in hypertension.

Design and Method:

A large community-based cross-sectional study was conducted between 2009 and 2013 to recruit participants in Changsha, China, and to evaluate and the distribution of various TCMC and the association of different TCMC with hypertension risk. A questionnaire was used to assess TCMC including 68 items. Age, gender, occupation, alcohol/smoke intake, family history, body mass index (BMI), blood pressure (BP) and blood test in part respondents were collected. The association between independent factors and each TCMCs, as well as TCMCs and the prevalence and control rate were analyzed. Prediction prevalence model of hypertension were established by Logistic analysis with TCMC and other factors.

Results:

Finally, 144,439 subjects completed TCMC evaluation and nine TCMCs were identified. The majority (96.8%) of participants had only one TCMC. 65.4% presented balanced constitution. Statistical analysis indicated that age, BMI, occupation, smoking and alcohol intake, hemoglobin, fasting blood-glucose, cholesterol, triglyceride, creatinine, potassium and sodium in blood were different in balance and unbalance TCMCs groups. Hypertension prevalence among unbalanced TCMC groups was much higher than that among balanced TCMC groups (30.4% vs. 9.1%; P < 0.01). Adjusted logistic regression model indicated that those with phlegm wetness, yin deficiency and blood stasis were more likely to be suffering from hypertension. Additionally, wetness heat had the worst systolic and diastolic BP control levels.

Conclusions:

TCMCs have an impact on incidence and therapy effect of hypertension and more attention should be paid to susceptible hypertension TCMCs, and corresponding therapeutic treatment be developed according to different TCMC.

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