To explore the relationship between Long-term arterial stiffness and plasma high- sensitivity C reactive protein (hs-CRP) levels in healthy adults.Design and Method:
Study cohort included 231 healthy youth individuals, aged 24 to 33 years at baseline in 2005. These subjects were followed up in 2013. General information collections, physical examinations including blood pressure, height, weight, pulse rate, as well as biochemistry indexes measurements including fasting glucose, blood lipid, hs-CRP and so on, were carried out at both baseline and follow-up periods. Brachial-ankle pulse wave velocity (baPWV) was recorded by noninvasive automatic waveform analyzer in 2013.Results:
The levels of baseline and follow-up hs-CRP were 0.36 (0.18∼0.72) mg/L and 0.50 (0.22∼1.05) mg/L respectively. Individuals whose hs-CRP levels of both periods sustained at the 90th percentile and above had higher baPWV than those whose hs-CRP levels sustained at the below of 90th percentile [(1437.9 ± 142.0) vs. (1282.8 ± 170.9) cm/s, P = 0.019]. Spearman correlation analysis indicated that the baseline CRP levels were positively correlated with follow-up CRP levels P < 0.001 and baPWV was also correlated with baseline CRP and follow-up CRP positively (all P < 0.05). Stepwise multivariate regression analysis showed that, after adjusting for age, sex and various confounders, follow-up CRP levels, but not baseline CRP levels, were independently correlated with baPWV [(b = 0.146 P = 0.012) and (b = 0.641 P = 0.985), respectively]. After excluding hypertensive and diabetic subjects, baseline CRP levels were not independent predicting factor of baPWV (b = 0.853 P = 0.985), but follow-up CRP levels remained correlative to baPWV (b = 0.157 P = 0.025).Conclusions:
Plasma hs-CRP level in early phase plasma cannot independently predict the long-term baPWV in healthy adults.