PS 05-44 OSTEOPONTIN LEVELS ARE ASSOCIATED WITH CORONARY PLAQUE CALCIFICATION IN ANGINA PECTORIS PATIENTS.

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Abstract

Objective:

Recently we can distinguish unstable coronary plaque from stable plaque with some image modalities such as intravascular ultrasound, CT and MRI, but cannot with blood biomarker. An inflammatory cytokine: Osteopontin (OPN) exist in the aorta, the carotid and the coronary plaque, particularly in the calcified plaque. In addition, association of the cardiovascular disease (CVD), the restenosis of coronary stent and OPN level were reported. We study to examine quantitative and qualitative evaluation of coronary plaque and evaluate the prediction ability of cardiovascular event. We performed clinical study.

Design and Method:

In clinical study, we received the approval of the Ethical Review Board for a clinical study in Ehime University and approval of patients. Thirty patients (10 were essential hypertension (EHT): as control group, 20 were angina pectoris (AP)) were included and measured plasma OPN and N-half OPN concentration by ELISA. Angina patients received coronary CT (256-slice multidetector CT made by Philips) for evaluating coronary plaque and coronary calcium score (CCS).

Results:

Plasma OPN (317.2 ± 111.4 ng/ml) in AP group was higher than EHT group (102.2 ± 92.4 ng/ml). There was no difference in the concentration of N-half OPN between both groups (AP 7.2 ± 5.2 vs EHT 10.9 ± 7.1 pmol/L). AP patients who had higher CCS (>100) tended to show higher plasma OPN level (336.4 ± 85.9 ng/ml) than lower CCS (<100) AP patients (289.2 ± 96.5 ng/ml).

Conclusions:

Plasma OPN levels in AP patients are higher than EHT patients and have the ability to be a blood biomarker of the unstable plaque rupture.

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