To study clinical differences of arterial hypertension; to conduct both standard comparative analysis of 24-hour blood pressure monitoring and cosinor-analysis for chronobiological assessment of AH circadian rhythms in shift workers of the Arctic polar region and native residents of Tyumen city.Design and Method:
373 patients with AH stage I-II in the control group and 144 patients with AH stage I-II in the comparative group were examined and underwent 24-hour blood pressure monitoring, echocardiography, brachiocephalic artery ultrasound, treadmill ergometer test, 24-hour ECG holter monitoring.Results:
In the conditions of shiftwork in the Arctic clinical implications of AH were more evident and associated with structural heart alterations, high frequency of atherosclerosis in brachiocephalic arteries, dislipidemy, low exercise tolerance and level of adaptive potential. In northern citizens with AH circadian blood pressure profile was associated with low circadian rhythm indices, high BP variability, mainly night hyperbaric overload that explains high frequency of AH circadian blood pressure profile «non dipper» and «night peaker».Conclusions:
Chronobiological disturbances in AH circadian rhythm in the conditions of shiftwork was caused by the malfunction of correspondence in internal and external cueing of physiological processes (desynchronosis) influenced by the conditions of shiftwork.