PS 05-53 THE ASYMPTOMATIC HYPERURICEMIA DIAGNOSIS IN THE REAL WORLD: FROM THEORY TO THE PRACTICE.

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Abstract

Objective:

Asymptomatic hyper-uricemia (AHU) - a condition defined for serum uric acid (SUA) levels ≥ 6.8 mg/dL in which neither of urate crystal deposition disease, such as gout or SUA renal disease occurred - is considered independently to crystal deposition a marker of hypertension, chronic kidney and insulin resistance syndrome. However, in clinical practice AHU is frequently under-diagnosed as different reference ranges of SUA were used. The aim of this study was to investigate the effect of an experimental program for Continuing Education in Medicine (ECM) to improve the diagnosis of AHU.

Design and Method:

In the setting of the general and laboratory medicine, from February to June 2015, 5 ECM courses were ruled out in 2 towns of northeast (Rovigo) and central (Arezzo) of Italy. By questionnaire was asked participant to indicate for which SUA levels AHU was diagnosed. At baseline the data collected were compared with SUA standard levels (SUA ≥ 7 mg/dL) commonly used to diagnose AHU. Six-months after the end of ECM the SUA levels in the medical records (MD) of patients afferent firstly to our Hypertension Centre were checked.

Results:

254 MD were analysed (mean age of patients was 62.2 ± 6.4, not different between gender). At baseline, SUA levels ranged from 2.5 to 8.4 mg/dL and AHU was undiagnosed in 25.4 % of cases. At the follow-up a new range of SUA (from 3.2 to 7.0 mg/dL) was observed in about of 90% of medical records analysed.

Conclusions:

We strongly believe in the importance of training and continuing education, and pay special attention to the feedback on the effectiveness of the courses promoted. Waiting of the results of the ongoing interventional trials on AHU treatment, we believe to have increase the knowledge in the clinical practice of this condition.

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