PS 05-60 THE ASSOCIATION OF CENTRAL AORTIC STIFFNESS WITH LEFT ATRIAL PHASIC FUNCTION IN PATIENTS WITH HYPERTENSION: A STUDY WITH SPECKLE-TRACKING ECHOCARDIOGRAPHY

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Abstract

Objective:

We aimed to explore the relationship between central aortic stiffness and left atrial (LA) function in hypertensive (HTN) patients.

Design and Method:

2D-speckle-tracking strain echocardiography was performed on 166 HTN (82male, 56 ± 14 years) with preserved LV ejection fraction (EF > 50%). Phasic LA function (reservoir, conduit, contractile) was analyzed. Global longitudinal LA strain (LA LS) was measured as an average value from apical four- and two-chamber views. Central hemodynamics including central pulse pressure (PP), PP amplification (PPA), augmentation index (AIx@75) and pulse wave velocity (PWV) were measured. Subjects were divided into 3 groups according to the tertile values of pulse pressure amplification (PPA) [Group 1 (n = 59), low PPA; Group 2 (n = 54), medium PPA; Group 3 (n = 53), high PPA].

Results:

Central hemodynamic parameters showed significant correlations with global LALS (AI@75: r = −0.18, p = 0.03; PWV: r = −0.25, p < 0.01; PPA: r = 0.21, p = 0.01), passive LA EF, reflecting LA conduit function (AIx @75: r = −0.29, p < 0.01: PPA: r = 0.27, p < 0.01), and LA volume index (LAVI) (PPA:r = −0.23, p = 0.02), while no significant correlation between peripheral PP and LA functional parameters was noted. Group 3 was younger and included more men, however, other baseline characteristics were not different among 3 groups. Global LALS, passive LA EF, and LA volume index (LAVI) and E/e’ differed significantly different among the groups. Mean value of global LALS differed significantly among all 3 groups, while mean value of passive LAEF and LAVI were not different between group 1 and 2. Multivariate analysis revealed independent correlation between PPA and LALS (p = 0.03) in women after adjustment of age, peripheral SBP, LAVI and passive EF.

Conclusions:

The central hemodynamic showed better correlations with LA functional parameters than peripheral hemodynamic parameters. Global LALS better correlated with PPA than other LA functional parameters in women.

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