PS 05-68 NO CROSS-SECTIONAL ASSOCIATION FOUND BETWEEN SKIN ADVANCED GLYCATION END PRODUCTS (AGE) AND ARTERIAL STIFFNESS IN A NON-HOSPITALIZED ELDERLY POPULATION

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Abstract

Objective:

Evaluation of transdermal Advanced Glycation End (AGE) products autofluorescence (skin-AF) is a new method for estimation of exposure to hyperglycaemia and oxidative stress. Previous studies have shown that skin-AF is elevated in patients with some chronic disease conditions (End-stage renal disease, ESRD; type-1 diabetes) and atherosclerosis, but population-based data on the association with arteriosclerosis (arterial stiffness) are sparse.

Design and Method:

We examined a total of 498 elderly subjects (mean age 72 years, 39% men) from the Malmö Diet Cancer–Cardiovascular cohort during 2007–2012. Methods included measurement of skin-AF (AgeReader®, Diagnoptics) and assessment by carotid-femoral pulse wave velocity, (c-f PWV) (SphygmoCor®, AtCor Medical), in addition to a number of lab-analyses and data on medical history. Subjects with arrhythmias were excluded for technical reasons.

Results:

Skin-AF correlated significantly with c-f PWV (r = 0.13, p = 0.005), but after adjustment for chronological age, mean arterial pressure (MAP), and heart rate (HR), this became a non-significant trend (β = 0.07, p = 0.08). Further adjustment also for sex, diabetes, renal function and antihypertensive drug treatment resulted in non-significant findings (β = 0.02, p > 0.5). The adjusted associations between skin-AF and c-f PWV were non-significant in subjects with and without diabetes and in both sexes. In older subjects (>72 years, median) a positive correlation was seen (r = 0.164, p = 0.009), but became non-significant following adjustments. In subjects with normoglycaemia, a positive correlation was found (r = 0.225, p = 0.023), but was lost following full adjustment.

Conclusions:

Skin-AF for AGE is not significantly associated with measures of arterial stiffness (c-f PWV) in a non-hospitalized elderly population following adjustments. This could indicate that such associations could be different from that seen in patients with chronic disease or atherosclerosis, or that skin-AF mirrors oxidative stress exposure of greater relevance for atherosclerosis (intima) than arteriosclerosis (media).

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