PS 05-72 CENTRAL PRESSURE AND VASCULAR STIFFNESS IN PATIENTS WITH ARTERIAL HYPERTENSION AND METABOLIC DISORDERS ACCORDING TO DAILY MONITORING

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Abstract

Objective:

To conduct a comparative assessment of central (aortic) pressure and vascular stiffness in patients with diabetes mellitus type 2 (DM) and those with metabolic syndrome (MS) in combination with arterial hypertension (AH) 1–2 degrees.

Design and Method:

Study included 91 subjects. Group 1 consisted of 46 patients with diabetes, the group 2 included 45 patients with MS. Patients were matched for age, sex, height, BMI, office BP values. Structural and functional properties of the great arteries were measured using the technology Vasotens (“Peter Telegin”, Russia). The mean daily values of the central (aortic) pressure parameters were determined: SBPao, DBPao, PPao; pulse wave velocity in the aorta (PWVao), the propagation time of the reflected wave.

Results:

at a comparable level of office blood pressure patients with DM and MS differed on parameters of DBPao and PPao according to daily monitoring. In patients with diabetes DBPao values were significantly lower – 80.9 ± 8.8 mmHg, in the comparison group – 88.5 ± 7.9 mmHg (p < 0.01). PPao in the comparative groups was 46 (41; 53) and 40 (37; 43) mmHg, respectively (p < 0.01). Patients of both groups did not differ on the SBPao level: Group 1–126 (119; 139) mmHg in group 2–129.2 ± 8.9 mmHg (NS). Parameter RWTT in diabetic patients was 128.7 ± 11.0 ms, in patients with MS - 138,5 (132; 149) ms (p < 0.01). Aortic PWV (PWVao) in group 2 was significantly lower (8.2 ± 0.8 m/s) compared with group 1 (9.03 ± 0.9) (p < 0.01).

Conclusions:

On the parameters of ambulatory monitoring of aortic pressure and vascular stiffness, patients with diabetes mellitus and arterial hypertension were significantly different from those with the metabolic syndrome, which is probably due to the acceleration of atherosclerosis in large arteries on the background of hyperglycemia.

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