Arterial stiffness is a major contributor to cardiovascular disease. Recently, pulse wave velocity (PWV) is used to assess arterial stiffness. But, few studies have assessed arterial stiffness using real arterial blood pressure (BP).Design and Method:
A total of 54 patients who underwent coronary angiography (CAG) via radial approach were enrolled. All patients were recorded brachial arterial (BA) BP curve via direct radial sheath during BP measurement using automated BP machine (Omron HEM 7080IT). In BA BP curve, all patients were measured the degree of changes in BP during deflation twice. ‘Baseline BP’ (bBP) is defined as the BP at first pulse during BP cuff deflation. ‘Peak BP’ (pBP) is defined as the highest BP during BP cuff deflation. ‘Stable BP’ (sBP) is defined as the lowest BP after BP cuff deflation. Difference between bBP and pBP (BPP) is calculated as ‘pBP - bBP’. Difference between pBP and sBP (PSP) is calculated as ‘pBP - sBP’. Difference Values of BPP and PSP were adjusted by BA systolic BP (SBP). Adjusted BPP (aBPP) is calculated as (pBP - bBP)/BA SBP, and adjusted PSP (aPSP) is calculated as (pBP - sBP)/BA SBP. Of 54 patients, 29 patients were measured brachial-ankle PWV (baPWV). All baPWV were performed within 5 days after CAG.Results:
Mean age was 63.4 years and female was 44.4% (n = 24). Mean aBPP was 0.625 ± 0.110, and mean aPSP was 0.140 ± 0.483. The aBPP was moderately positive correlated with baPWV (r = 0.463, p = 0.011) and aPSP was also moderately positive correlation with baPWV (r = 0.493, p = 0.007). In multivariate analysis after adjustment, aBPP (p = 0.033) and aPSP (p = 0.022) were correlated with baPWV.Conclusions:
The differences of BP in accordance with rise and fall of BP after re-flow of brachial artery might be predict arterial stiffness.