It is difficult to quantify arterial stiffness directly in a focal area of elastic artery such as the aorta within these modalities. The purpose of this study was to determine the feasibility of assessment of aortic distensibility (AD) with analysis of Cardiac computed tomography (CCT) by comparing distensibility of the descending aorta between patients with coronary artery disease (CAD group) and without CAD (non-CAD group).Design and Method:
The study was a retrospective analysis of the findings in 69 patients who performed cardiac MDCT for evaluation of chest pain symptoms (n = 34 in CAD group, n = 35 in non-CAD group). The 69 subjects was performed 64 channel cardiac MDCT and Scan data were reconstructed at 20 phases between 0% and 95% of the R-R intervals with an increment of 5%. Pixel-based measurements of arterial dimensions were performed at 1 cross-section of the descending aorta in a transverse plane at the aortic valve level. End diastole area was measured at 95% of R-R interval and end systolic area was measured at 35% of R-R interval. Aortic distensibility was calculated as follows: AD = (end systolic area - end diastolic area)/ (end diastolic area × pulse pressure). For the measurement of pulse wave velocity (PWV), carotid-femoral (cfPWV), femoral-dorsalis (fdPWV) and carotid-radial (crPWV) was measured with the subject in a supine position using automatic device.Results:
Hypertension was significantly higher in CAD group than non-CAD group. Figure showed the differences of AD and PWV between CAG group and non-CAD group. The AD was significantly smaller in patients with CAD (AD; change in area/mmHg: 1.53 ± 1.11 × 10–3 in CAD vs 2.17 ± 1.18 × 10–3 in without CAD, p = 0.002).Conclusions:
AD is associated with atherosclerosis of the coronary arteries. Cardiac CT enables to assess direct and noninvasive measurements of aortic distensibility.