To study the occurrence of hypertension among subjects referred for health check-up and its correlation with biochemical parameters such as fasting blood glucose (FBS), uric acid (UA), lipid profile and liver enzymes.Design and method:
The study was conducted among 3200 subjects referred for health check-up in hospital. Subjects were classified into four groups according to Indian guidelines on hypertension (Group A normotensive (BP < 140/90YmmHg, without antihypertensive drugs); Group B:controlled hypertension (BP <140/90YmmHg, with antihypertensive drugs) Group C:uncontrolled hypertension (BP = 140/90YmmHg, with antihypertensive drugs) and Group D: newly diagnosed hypertension (BP = 140/90 with no history of hypertension). Twelve hour fasting blood sampling was done. Elevated FBS defined as levels = 126 mg/dL. Hyperuricemia was defined as UA >7Ymg/dl. Abnormal level of total cholesterol (TC), total triglyceride (TG), low-density lipoprotein (LDL), and low high-density lipoprotein (HDL) cholesterol were defined as = 240, = 200, = 160 and = 40Ymg/dL, respectively. Data was analyzed using SPSS 14.0.Results:
Out of 3200 subjects (71% males), occurrence of hypertension was 34%. The occurrence rate of hypertension shows an upward trend as age advances. Distribution of subjects in Group A,B,C and Group D were 65.5%, 8.9%, 8.6%, 17% respectively. An elevated level of FBS and UA was in 11% and 14.5% of subjects. Low level of HDL was in 40%. High TC was in women (8.4%) and men (5.8%). However high TG was observed in male (14.5 %) compare to those found in women (8.8%). Elevated SGOT and SGPT (> 40 IU/L) was in 6.74% and 20%. Hypertensive group B, C and D had significantly higher FBS, UA, lipid profile and liver enzymes compare to normotensive group A.Conclusions:
The occurrence of hypertension was 34%. Hypertension was detected first time during study in 17%. Present study results revealed positive correlation between hypertension and FBS, UA, lipid profile and liver enzymes levels.