PS 06-26 MATERNAL PRENATAL AND LIFE-STYLE FACTORS AND CATCH-UP GROWTH AT EARLY CHILDHOOD: HOW THESE INTERACT ON LIFE-COURSE OFFSPRING BLOOD PRESSURE AT ADULTHOOD?

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Abstract

Objective:

We examine the life course association (childhood to young adulthood) between blood pressure and prenatal and early life potential predictors.

Design and Method:

Offspring systolic and diastolic blood pressure (SPB, DBP) included for 3793, 3782, 2628 and 1780 at 5, 14, 21 and 30 years from Mater-University of Queensland Study of Pregnancy longitudinal study. Individual pulse pleasure (PP) was equated. General estimation equation with time interaction modelling were performed to determine prenatal and early life potential predictors for offspring's PP, SBP and DBP.

Results:

Prenatal and antenatal maternal factors such as smoking at late pregnancy [Adjusted Coff.:0.58 (95% CI:0.16, 1.00)] [0.14 (−0.40, 0.68)] [−0.42 (−0.82, −0.02)], maternal age [0.45 (−0.09, 0.98)] [1.04 (0.34, 1.75)] [0.58 (0.06, 1.11)], hypertensive disorder in pregnancy [0.36 (−0.30, 1.03)] [1.77 (0.90, 2.64)] [1.42 (0.77, 2.07), pregnancy overweight and obesity [−0.76 (−1.30, −0.23)] [0.44 (−0.27, 1.15)] [1.19 (0.66, 1.73)], gestational age [−0.19 (−0.31, −0.08)] [−0.28 (−0.43, −0.13)] [−0.09 (−0.20, 0.02)], and offspring's catch-up growth from birth to 5 years [1.30 (0.82, 1.78)], [2.93 (2.28, 3.58)] [1.61 (1.06–2.15)], breastfeeding upto 6 months [0.91 (0.37, 1.46)] [0.80 (0.09, 1.51)] [−0.10 (−0.63, 0.42)] and female sex [−6.64 (−7.02, −6.26)] [−7.51 (−8.01, −7.01)] [−0.92 (−1.29, −0.55)] were significantly associated with life course increase on the offspring's PP, SBP and DBP respectively from childhood to young adulthood.

Conclusions:

Due to sustainably increasing in prevalence of hypertension and a significant epigenetic relation with BP, prevention strategies should be first concentrated from prenatal period especially strict life style modification at late pregnancy. Reinforce in life style control needs to start form early childhood for primary prevention of hypertension as well.

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