OS 17-07 NOCTURNAL HYPERTENSION IS ASSOCIATED WITH RETINAL VEIN OCCLUSION

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Abstract

Objective:

Retinal damages have been suggested a surrogate marker of end-organ damage and prognostic marker in hypertensive patients. Retinal vein occlusion (RVO), one of common retinal vascular disorders has been known to be related to hypertension. However, the association between RVO and 24 hour ambulatory blood pressure monitoring (ABPM) was largely unknown.

Design and Method:

ABPM and retinal exam were done in 955 consecutive subjects enrolled in Cardiovascular and Metabolic Disease Etiology Research Center - HIgh Risk Cohort (CMERC-HI, NCT02003781). Nocturnal hypertension (HTN) was defined as mean night systolic blood pressure (SBP) > 120 mmHg or diastolic BP (DBP) > 70 mmHg.

Results:

RVO was found in 28 (2.9%) asymptomatic patients and nocturnal hypertension in 604 (63.2%) patients. RVO patients had higher brachial SBP (140±25 vs. 130 ± 17, p = 0.032) compare to those without RVO. There were no significant differences in age, gender, brachial DBP, heart rate, body mass index (BMI), estimated glomerular filtration rate (eGFR), glucose and cholesterol levels between RVO and non-RVO Group. The RVO patients had higher 24 hour mean SBP/DBP (141 ± 19/83 ± 10 vs. 130 ± 15/78 ± 8, p < 0.001/p = 0.002, respectively), day mean SBP/DBP (145 ± 19/86 ± 10 vs. 135 ± 15/81 ± 9, p < 0.001/p = 0.012, respectively), and nocturnal mean SBP/DBP (133 ± 20/79 ± 11 vs. 121 ± 17/73 ± 9, p < 0.001/p = 0.001, respectively) compared to those without RVO. Multivariate logistic regression analysis revealed that RVO was independently associated with nocturnal HTN after adjusting for other cardiovascular risk factors including age, gender, BMI, brachial SBP, heart rate, and eGFR (odd ratio; 3.7659, 95% confidence interval; 1.062–13.384, p = 0.040).

Conclusions:

We reported that RVO was related to APMB parameters, especially nocturnal hypertension. Hypertensive patients with nocturnal HTN should be closely monitored for the development of RVO and related vision loss.

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