One of the first disorders of affection subcortical brain structures in arterial hypertension (AH) is a decrease in mental processes, intellectual rigidity. To investigate the cognitive disorders (CD) in AH patients 1–2 stages of working age and the effectiveness of nootropic agent (phenibutum) and anticholinergic drug (ipidacrinum) in combined antihypertensive therapy.Design and Method:
Observed 60 patients with controlled AH 1–2 stages and CD. The median age–55,3 ± 9,1 years and duration of AH–10,2 ± 5,8 years. All patients were examined according to ESC, 2013; JNC, 2014 recommendations. Neuropsychological diagnostics included integrated assessment of cognitive functioning by MMSE scale; quality of life (QL) − by «SF-36 HEALTH STATUS SURVEY». All patients received a personalized antihypertensive therapy, 30 of them were still added nootropic agent phenibutum–250 mg 3 times a day and anticholinergic drug ipidacrinum–10 mg 2 times a day for 45 days.Results:
Discovered reduction in QL of working age patients on all counts «SF-36», which was significantly associated with the presence of CD investigated varying degrees of severity: mild CP − 35.4%, moderate CP–56.1% and 8.5%–mild dementia. In patients who were prescribed additional phenibutum and ipidacrinum recorded a significant improvement of integrated indicators of intelligence in the areas of attention, concentration, reaction speed and verbal memory, reduced levels of reactive and personal anxiety, QL increased by 41.8%.Conclusions:
Patients with arterial hypertension should be conducted neuropsychological examination for early determination of cognitive disorders and their timely, adequate correction.