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The aim of the study was to address the impact of hemorrhoid on the development of CHD with or without concomitant comorbidities.Database was derived from Taiwanese national insurance beneficiaries. Study subjects were composed of patients with hemorrhoid (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 455) (n = 33034), and a comparison cohort without the hemorrhoid (n = 132136) from 2000 to 2010. Both cohorts were matched by sex, age, and the index year in a 1:4 ratio. Cox proportional hazards regression was used to assess the hazard ratio (HR) of CHD associated with hemorrhoid.The overall incidence rates of CHD were 9.91 per 1000 person-years in the hemorrhoid patients and 7.28 per 1000 person-years in the matched control patients with an adjusted hazard ratio (HR) of 1.27 (95% CI = 1.21–1.33; p < 0.001) within 12 years of follow up. Furthermore, the hemorrhoid patients with any one or two concomitant comorbidities were associated with higher risk of CHD compared with those with neither hemorrhoid nor comorbidity (adjusted HR = 2.24, 95% CI: 2.04–2.45; p < 0.001, and adjusted HR = 3.23, 95% CI: 2.97–3.50; p < 0.001; respectively).Our finding suggested that patients with hemorrhoid are at an increased risk of subsequent CHD development. Furthermore, a diagnosis of hemorrhoid can enhance the risk of incident CHD among subjects with CHD -associated risk factors.