MPS 08-05 Association of CETP gene D442G polymorphisms with myocardial infarction and stroke in Chinese population

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Abstract

Objective:

Genetic variants of proteins involved in lipid metabolism may play an important role in determining the susceptibility for complications associated with cardiovascular and cerebrovascular diseases. Goal of the present study was to determine the association of cholesteryl ester transfer (CETP) gene D442G (rs2303790) polymorphisms with myocardial infarction and stroke.

Design and Method:

We conducted two case–control association studies (one cohort of 2325 myocardial infarction patients and 2620 unrelated controls, another cohort of 3960 stroke patients and 3654 controls)from the Chinese population. Genotyping of the rs2303790 SNP was performed by the TaqMan Real Time PCR method.

Results:

In both cohorts CETP D442G (rs2303790) polymorphisms was associated with levels of HDL cholesterol and ApoA1 (all p < 0.001). After adjusting for age, sex, BMI and other factors, CETP D442G has no association with myocardial infarction and hemorrhagic stroke. In subgroup of stroke, the SNP showed a significant association with Ischemic stroke adjusting by HDL cholesterol (odds ratio 1.39, 95%CI: 1.098–1.772, p = 0.0065, dominant model) or ApoA1 (odds ratio 1.47, 95%CI: 1.152–1.876, p = 0.0024, dominant model).

Conclusions:

The present study has shown that in the Chinese population CETP D442G polymorphisms was associated with HDL cholesterol and ApoA1 levels, but not myocardial infarction and hemorrhagic stroke. The detailed physiological effects of SNP and Ischemic stroke needed to be future defined.

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