MPS 10-05 The Association Between Appendicular Body Mass and Brachial Ankle Pulse Wave Velocity in Elderly

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Abstract

Objective:

Arterial stiffness, which can be evaluated by measuring pulse wave velocity (PWV), is associated with the risk of cardiovascular disease. Sarcopenia, loss of mass or strength of the skeletal muscles, also associated with adverse outcomes in elderly population. We evaluated the relationship between appendicular body mass adjusted with height and brachial ankle pulse wave velocity in community-dwelling elderly people.

Design and Method:

We studied 352 participants of the Korean Longitudinal Study on Health and Aging (KLoSHA) whose aged 65 and older. Appendicular muscle mass (ASM) was measured by dual-energy x-ray absorptiometry (DXA). Brachial-ankle pulse-wave velocity (baPWV) was measured as an index of arterial stiffness. We used reference cut-off values from previous studies of the baPWV, defined as 1750.0 cm/sec.

Results:

216 (61.4%) patients have baPWV over 1750 cm/sec. In multiple regression analysis, after controlling group of age (65 - 74, 75 - 84, over 85), sex, systolic blood pressure, presence of hypertension and diabetes, low density lipoprotein, uric acid, and urine albumin creatinine ratio, ASM/height2 (β = −0.190, p = 0.010) had significant negative association with maximum baPWV. The fully-adjusted odds ratios per 1 kg/m2 were 0.715 (95% CI: 0.519 – 0.984, p = 0.040) for baPWV cut-off value of 1750.0 cm/sec.

Conclusions:

This study provides that lower appendicular muscle mass was associated with increased arterial stiffness in community dwelling elderly.

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