MPS 11-08 Low power programmable pulse current source for wireless nerve stimulation and recording in small rodent

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Abstract

Objective:

To study neural reflex mechanisms in hypertension and neural disease in small rodent (rats and mice), implantable wireless nerve stimulation and recording system is required. We aim initially at establishing a low power programmable pulse current source for nerve wireless stimulation and recording in small rodent.

Design and Method:

A low power programmable pulse current source was designed for nerve stimulation. Aortic depressor nerve (AND), a pure afferent nerve of baroreflex sensor located in Aorta, was selected for low power stimulation (3 V/0.1–0.2 mA/200 micro seconds pulse duration at 5/10/20 Hz for 10 seconds) combined with recording intra-arterial blood pressure (BP) and heart rate (HR), and renal sympathetic nerve activity (RSNA) in 10 adult Wistar male rats (BW: 314 ± 2 g). A femoral arterial catheter was implanted in rat. Twenty four hours later, ADN and RSNA were isolated respectively for placement of electrodes. During stimulation on ADN, BP, HR, and RSNA were synchronised recorded.

Results:

Low power stimulation on ADN at 5, 10, and 20 HZ for 10 s induced significantly dose-response of decreases in SBPs (25 ± 6, 46 ± 9, and 58 ± 9 mmHg, p < 0.01) and HRs (97 ± 17, 132 ± 13, and 193 ± 25 bpm, p < 0.01). RSNA were also decreased during the stimulation (see figure).

Conclusions:

The results demonstrate that low power programmable pulse current source can be applied to small rodent for studying neural mechanism related diseases, for instance, sympathetic never system involved pharmacotherapy resistant hypertension. The neural low power stimulation profile will be integrated into an implantable wireless nerve stimulating and recording system for small rodent.

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