ISH NIA PS 02-01 Neck Circumference is Associated with Systolic Blood Pressure: A Community-based Prospective Cohort Study

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Abstract

Objective:

The association between upper body subcutaneous fat, represented by neck circumference (NC), and blood pressure was explored.

Design and Method:

The data was retrieved from the Korean Genome and Epidemiology Study (KoGES) cohort. A total of 35,709 cohort subjects were screened. After exclusion, 1,814 male and 1,495 female subjects were eligible for final analysis. The subjects with hypertension was classified as who answered a question which about experience of diagnosed hypertension by any physicians. Multiple linear regression analysis was performed to elucidate the association between NC and cardiovascular risks.

Results:

A total of 1,814 (54.8%) male and 1,495 (45.2%) female subjects were analyzed. The median NC was 37.6 (36.1–39.0) in male and 32.7 (31.5–34.0) in female, and subjects were divided into two groups according to the median value of NC, respectively. The high NC group showed significantly higher prevalence of hypertension (male: 63 [7.3%] vs 139 [16.4%], P < 0.001; female: 53 [7.4%] vs 109 [15.4%], P < 0.001) and diabetes (50 [5.7%] vs 91 [10.7%], P < 0.001; 13 [1.8%] vs 49 [6.9%], P < 0.001), systolic BP (111.5 ± 16.6 vs 117.1 ± 16.9, P < 0.001; 105.1 ± 15.2 vs 112.5 ± 17.3, P < 0.001), diastolic BP (75.6 ± 12.1 vs 80.0 ± 12.0, P < 0.001; 69.7 ± 10.5 vs 74.2 ± 11.7, P < 0.001), and pulse pressure (36.0 ± 8.5 vs 37.1 ± 9.3, P = 0.008; 35.4 ± 8.6 vs 38.3 ± 10.5, P < 0.001). In multiple linear regression analysis, NC was independently associated with systolic BP in both genders even after adjustment for multiple confounding factors (per 10 mmHg, male: β=0.049, P = 0.040; female: β=0.094, P < 0.001). However, a significant relationship was not found with diastolic BP or pulse pressure.

Conclusions:

NC is independently associated with systolic BP in both gender groups. Upper body subcutaneous fat, chiefly represented by NC, may have a role in hypertension pathophysiology.

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