ISH NIA PS 02-08 Acute effects of Smoking over the endothelial function and central arterial hemodynamics in young healthy people

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The aim of this study was to assess the acute effects of smoking over the endothelial function and central arterial hemodynamics, in healthy and young smokers.

Design and Method:

Thirty healthy young individuals, were allocated into two groups, matched for gender and age, according to their smoking habits: control group (CG; n = 15 non-smokers) and intervention group (IG; n = 15 smokers). All the individuals were submitted to two clinical evaluations, basal and following 30 minutes (after smoking a cigar in the IG). Weight, height, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), flow-mediated dilation (FMD), aortic pulse wave velocity (PWV) and pulse wave analysis over the carotid artery (PWA) were assessed.


CG and IG groups had similar baseline clinical and demographic characteristics, although the IG showed lower baseline FMD values (7.53 ± 2.80% versus 12.47 ± 4.63% in the CG; p = 0.001). The pairwise analysis revealed significant variations in the IG, but not in the CG, with an increase in HR, brachial and central BP and PWV, and a significant decrease in FMD, revealing a important acute compromise of endothelium-dependent vasodilation after the cigar in the IG, with no changes in the CG (cf. table.


Smoking has an acute and noteworthy pernicious effect over the vascular function in young and healthy individuals, compromising endothelium-dependent vasodilation, increasing heart rate, blood pressure and aortic stiffness.

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