ISH NIA PS 02-09 MONOTHERAPY EFFECTS OF TELMISARTAN ON MICROCIRCULATION IN PATIENTS WITH UNCOMPLICATED ARTERIAL HYPERTENSION (AH)

    loading  Checking for direct PDF access through Ovid

Abstract

Objective:

To evaluate telmisartan monotherapy effects on microcirculation in patients with uncomplicated arterial hypertension.

Design and Method:

20 patients (age 50,2 ± 12,8 years; male - 65%) with untreated uncomplicated grade I-II AH are included into the study. All patients were treated by telmisartan 80 mg during 8 weeks. At baseline and after 8 weeks the parameters of microcirculation were measured. The parameters of microcirculation were evaluated at baseline and after 8 weeks by laser Doppler flowmetry: index of microcirculation (IM, perf.units), which characterizes basal blood flow; occlusion test - capillary blood flow reserve (CBFR), which characterizes the reversibility of remodeling microvasculature; difference index of microcirculation (DIM), which indicates the degree of reduction in blood flow during occlusion; half-recovery time of capillary blood flow (T1/2,s), which characterizes the reactivity of the vascular bed; index of increase in capillary blood flow (IICBF, perf.units), which indicates an increase in vasoconstriction. Data presented as M ± m. Wilcoxon criteria for by-pair comparisons was used. p < 0,05 was considered significant.

Results:

After 8 weeks of treatment BP decreased from 154,4 ± 2,5/98,4 ± 1,8 mmHg to 136,2 ± 3,1/84,9 ± 2,5 mmHg (p = 0,0077). 55% of surveyed have reached target BP levels < 140/90 mmHg. 25% responded to treatment determined as decrease in systolic BP > 20 mmHg or diastolic BP > 10 mmHg. Significant increase (p < 0,05) of IM from 2,93 ± 0,39 perf.units to 4,22 ± 0,75 perf.units was observed. CBFR decreased from 391,1 ± 25,5% to 295,4 ± 29,2% (p < 0,05). According to the occlusion test were observed recovery of normal type reactions to arterial occlusion: DIM increased from 1,63 ± 0,30 perf.units to 2,27 ± 0,68 perf.units (p < 0,05). IICBF and T1/2 were not significantly changed.

Conclusions:

Telmisartan monotherapy (dose – 80 mg), 8-weeks course, contributes to restore normal hemodynamic type of microcirculation, normalizes microcirculation response to arterial occlusion and improves capillary blood flow reserve.

Related Topics

    loading  Loading Related Articles