PS 08-02 LIFESTYLE FACTORS AND ANTIHYPERTENSIVE TREATMENT OF VALSARTAN/AMLODIPINE SINGLE-PILL COMBINATION IN ESSENTIAL HYPERTENSION (CHINA STATUS II): AN OBSERVATIONAL STUDY

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Abstract

Objective:

In order to observe lifestyle factors and antihypertensive response to valsartan/amlodipine (Val/Aml, 80/5 mg), the data from the CHINA STATUS II study was further analysed.

Design and Method:

A total of 11312 patients (6456men and 4856 women), received Val/Aml treatment for 8 weeks. After the treatment at 4 weeks and 8 weeks, we compared the proportion of patients not achieving the target systolic blood pressure (SBP; ≥140 mmHg) or diastolic blood pressure (DBP; ≥ 90 mmHg) in different lifestyle factors by T test or Chi-square test. There were hazard ratios (HRs) for not achieving the target BP by Mantel-Haenszel according to different lifestyle factors in men and women; the two-sided probability for the Fisher exact test was calculated.

Results:

Both women and men’ appropriate physical activity can early achieved the target DBP (HR 0.92, 95% IC 0.88–0.97 in women and HR 0.91,95% IC 0.88–0.94 in men at 4 weeks; HR 0.72, 95% IC 0.63–0.82 in women and HR 0.80, 95% IC 0.73–0.89 in men at 8weeks, respectively). There was the higher education, the more early achieving the target DBP in both women (HR 0.72, 95% IC 0.63–0.82) and men (HR 0.80, 95% IC 0.73–0.89)) at 4week. Current smoke increased HR for not achieving the target DBP in women (HR 1.47, 95% IC 1.04–2.07) at 4 week, while BMI ≥ 25 (HR 1.09, 95% IC 1.00–1.19 at 4 week and HR 1.32, 95%, IC 1.09–1.61at 8 week) and current alcohol drink (HR 1.31, 95% IC 1.05–1.63 at 8 week) increased HR for not achieving the target DBP in men.

Conclusions:

Healthy lifestyle factors are important in control BP in patients with antihypertensive Val/Aml treatment.

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