PS 08-17 EFFECTIVENESS COMPARISON BETWEEN LISINOPRIL AND AMLODIPINE IN MELANESIAN PATIENTS WITH HYPERTENSION

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Abstract

Objective:

To measure plasma renin activity (PRA) and compare the effectiveness of lisinopril and amlodipine in melanesian hypertensive patients to reduce blood pressure.

Design and Method:

Sixty eight subjects were randomly assigned into 2 groups, those receiving lisinopril 5 mg (34 subjects) and amlodipine 2.5 mg (34 subjects). Blood pressure, PRA and other baseline characteristics were measured before the intervention, and then evaluated every week. Dose of lisinopril and amlodipine will be increased in subjects who have not achieved blood pressure target, 10 mg to 20 mg and 5 mg to 10 mg, respectively. At the end of the fourth week, blood pressure is measured as the main clinical outcome. Seven subjects were drop out, four from lisinopril group and three from amlodipin group.

Results:

Plasma renin activity in this study population was 1.6 ng/ml/h (normal). Baseline characteristics did not differ between two groups, including blood pressure and PRA before intervention. Significant decrease in blood pressure occurred in both group after the intervention, including systolic blood pressure (SBP), diastolic (DBP) and mean arterial pressure (MAP). However, there are no differences in blood pressure reduction between lisinopril and amlodipine groups. (SBP 24.6 ± 9.3 vs 25.9 ± 8.9 mmHg, p = 0.56; DBP 13.3 ± 5.5 vs 11.4 ± 4.8 mmHg, p = 0.15; MAP 17.1 ± 5.6 vs 16.3 ± 5.0 mmHg, p = 0.55).

Conclusions:

Plasma renin activity in melanesian hypertensive patients was normal and administration of lisinopril showed no difference in blood pressure reduction compared with amlodipine.

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