PS 08-21 CONSIDERATION OF THE RELATIONSHIP BETWEEN THE BLOOD PRESSURE-RELATED PARAMETERS AND SARCOPENIA IN OLDER HYPERTENSIVE SUBJECTS

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Abstract

Objective:

Fall, as well as fracture, is one of the most important factors associated with transition to nursing care. The assessment of physical frailty or sarcopenia have attracted attention as a tool detecting the subjects having an increased risk for fall or fracture, however these have not been widely spread in Japan. On the other hand, the current Japanese guidelines for the management of hypertension mentioned that frailty should be considered when determining blood pressure target or therapeutic methods, however, the relationship between frailty or sarcopenia and hypertension has been still unclear. We examined the factors related to incidence of fall focusing on the relationship between sarcopenia and hypertension in the older subjects.

Design and Method:

152 consequence subjects who were over 65 years old and diagnosed as hypertension and admitted to Osaka University hospital, were recruited in this study. Body composition, muscle strength, physical ability and body measurements were performed. History of fall and prescriptions for hypertension were obtained. Blood pressure (BP), ankle-brachial index (ABI) and pulse wave velocity (PWV) were also measured. Sarcopenia was determined based on the criteria proposed by Asian Working Group for Sarcopenia.

Results:

The average age of this population was 75.8 and the prevalence of sarcopenia was 15.1%. Pulse pressure was significantly higher in sarcopenia group than in non-sarcopenia group, and ABI was lower in sarcopenia group. In non-sarcopenia group, systolic BP was significantly higher in the subjects with history of fall than in those without it, however systolic BP was lower in the subjects with history of fall than in those without it in sarcopenia group.

Conclusions:

Sarcopenia was associated with the parameters related to hypertension and the association between blood pressure and fall can be changed depending on the presence or absence of sarcopenia in older hypertensive subjects.

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