PS 08-26 CORRELATION BETWEEN ORTHOSTATIC HYPOTENSION WITH CIRCDIAN RHYTHM, LEFT VENTRICULAR STRUCTURE AND FUNCTION IN AGED PATIENTS WITH HYPERTENSION

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Abstract

Objective:

To investigate the correlation between Orthostatic hypotension with 24 hours ambulatory blood pressure circadian rhythm, left ventricular structure and function in eldly patients with hypertension.

Design and Method:

We enrolled 357 cases (Mean age: (68.85 ± 8.63). All the participants underwent 24hABPM and Cardiac ultrasonography. Based on orthostatic hypotension diagnostic criteria, the subjects were subdivided into 2 groups: 142 cases of OH group and the other 215 ones of non-OH group.

Results:

The mean 24 hours systolic blood pressure (24hSBP), night systolic blood pressure (nSBP) were higher in OH group than in non-OH group [(142.37 ± 16.69) vs(138.55 ± 16.22) mmHg, P = 0.03; (133.51 ± 14.13) vs (127.26 ± 13.63) mmHg,P = 0.00]. And a significantly more decrease of systolic blood pressure fall (SBPF) and diastolic blood pressure fall (DBPF) in OH group than in non-OH group[(6.17 ± 3.42) vs (7.08 ± 3.67)%,P = 0.02; (5.46 ± 2.69) vs (6.18 ± 3.21)%, P = 0.03]. Interventricular septal thickness in diastole(IVSD), left ventricular end-diastolic diameter(LVEDD), left ventricular mass index(LVMI) and left ventricular end-systolic diameter(LVESD) increased obviously in OH group than those in non-OH group [(10.79 ± 1.74) vs (10.35 ± 1.65) mm; (48.36 ± 5.13) vs (46.79 ± 6.05) mm, (128.48 ± 26.15) vs (122.64 ± 22.85)g/m2, (31.97 ± 5.06) vs (30.84 ± 4.81) mm; P = 0.02;0.01;0.03;0.03]. The ejection fraction(EF) and stroke volume(SV) were marked lower in OH group than in non-OH group.

Conclusions:

The hypertension is closely correlated to the abnormal circadian rhythm of 24hABPM and the damage of left ventricular structure and function in eldly patients with hypertension.

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