PS 08-32 THE PROTECTIVE EFFECT ON HYPERTENSION IN PATIENT WITH CHRONIC KIDNEY DISEASE

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Abstract

Objective:

Manganese (Mn) is one of the essential trace minerals and known to have anti-oxidative functions which could be related to regulate blood pressure. The purpose of our study was to evaluate the association between serum manganese levels and the blood pressure in patients with chronic kidney disease.

Design and Method:

This study was a cross-sectional study based on the hospitalized patients with kidney problem. Total 200 patients were enrolled, and they were divided into two groups according to the level of manganese. Cut-off value was 8 ug/L, which was the highest normal range of the protocol of the our center policy.

Results:

High manganese group significantly showed lower systolic blood pressure (127.1 ± 19.1 vs. 138.2 ± 30.1;p = 0.002) and higher eGFR level (60.2 ± 74.0 vs. 21.9 ± 28.8; p = 0.000). Also we analyzed the association between systolic blood pressure and 3 tertile groups of manganese level which showed significant difference (138.0 ± 30.3, 126.8 ± 19.5, 127.6 ± 18.9, respectively; p = 0.010). But there was no significant correlation between blood manganese level and diastolic blood pressure.

Conclusions:

These results suggest the protective effect of manganese in systolic blood pressure and chronic kidney disease.

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