[PS 08-45] EFFECTIVENESS GRANT OF ZINC TO LEVELS OF C-REACTIVE PROTEIN IN CHRONIC KIDNEY DISEASE PATIENTS THOSE UNDERGOING HAEMODIALYSIS REGULAR IN MOHAMMAD HOESIN HOSPITAL PALEMBANG

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Abstract

Objective:

Chronic inflammation effect on morbidity and mortality in hypertensive patients with CKD-HD. Research shows zinc reduce inflammation in patients with CKD-HD. This study to prove whether zinc supplementation lowers inflammation, seen from changes in CRP levels before and after administration of zinc or placebo for 12 weeks in patients with CKD-HD regular

Design and Method:

A single-blind study randomized clinical trials, research in Hemodialysis Installation RSMH Palembang March to June 2015. The research subject of regular HD patients with CKD-40 made history, physical examination, assessment of appetite, clinical laboratory tests and examination of CRP levels later divided randomly assigned (randomized) into the group received zinc and placebo groups. After week 12, subjects examined levels of CRP. During the follow-up period, 1 subject died, 2 subjects discontinued treatment because several times hospitalized and eventually stop treatment and 1 subject moved undergoing hemodialysis in other places, at the end of the study there were 36 subjects (18 subjects who received zinc and 18 subjects received placebo), which conducted the analysis.

Results:

The mean levels of CRP in the zinc before the study was 4.10 ± 1.40 mg / L and after 12 weeks of the study to 2.54 ± 1.75 mg / L. Contrary to the placebo group, the general decline in CRP levels in the zinc, amounting to −1.627 ± 1,874 mg / L. Paired t-test showed a mean reduction in CRP levels in the zinc group were statistically significant (p = 0.003). Comparing the mean change in CRP levels between groups, and the results showed differences in changes in CRP between zinc and placebo groups was statistically significant (p = 0.03)

Conclusions:

The provision of zinc effectively lowers CRP levels in patients with CKD-HD. Zinc supplementation can be used as an adjunctive therapy to reduce the incidence of chronic inflammation in patients with CKD-HD

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