Microalbuminuria is a risk factor for cardiovascular events and death in hypertensive patients. To predict an increase in albuminuria it is important to determine the intensification of antihypertensive treatment. In the present study, we assessed the association between the renal resistive index (RI) and future increases in albuminuria in patients with essential hypertension.Design and Method:
Sixty-six patients with essential hypertension were included in the study. Univariate and stepwise multivariate logistic regression analyses were used to identify the factors, including renal RI, that were significant independent determinants of increased in urinary albumin excretion (UAE), defined as an increase of > 50% in the urinary albumin-to-creatinine ratio over 2 years. Receiver operator characteristics curve analysis was used to select the optimal cut-off point that predicted an increase in urinary albumin excretion.Results:
RI was the only significant variable that predicted the increase in UAE, with the optimal cut-off value of renal RI that predicted this increase being 0.71 (sensitivity 52.4% and specificity 84.4%).Conclusions:
Renal RI is associated with the future increase in albuminuria in patients with essential hypertension.