PS 08-59 INDICATORS OF BLOOD PRESSURE IN WOMEN WITH CORONARY HEART DISEASE WITH ANDROGENIC COMPONENT IN DIFFERENT AGE CATEGORIES

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Abstract

Objective:

Adrogenization in women is a strong and independent factor that increases the risk of cardiovascular diseases, high blood pressure (BP), development arterial hypertension (AH) and coronary heart disease (CHD). The aim of the study is to study the BP in women with CHD with androgenic component of different age categories.

Design and Method:

A survey of 200 women underwent a CHD, of which only 20 have been identified androgenization, the presence of a combination of reduced estradiol (E) with simultaneous increase of testosterone (T), which is expressed in young patients decline E < 30 pg/ml and an increase in T > 0.6 ng/ml, and in menopausal women decline E < 15 pg/ml and increased T > 0.8 ng/ml. All surveyed carried out a full range of clinical and research tool for verification of CHD and laboratory tests to determine the hormones E and T. Surveyed patients in the morning mercury pulsometer measured BP and heart rate (HR) with the 5-minute intervals.

Results:

Among 20 examined women with CHD with androgenization, 13 of them were fertile age and only 7 - to menopause, which accounted for 16.5% and 5.8% respectively. Among women of fertile age in BP was recorded at 3 persons (23.0%), and in menopausal women - at 5, which amounted to 71.4%. Note that in both groups level as the systolic SBP and diastolic DBP was significantly higher among women in menopause (141.7 and 88.6 mmHg, respectively, compared with those of fertile age (122.7 and 81.1 mmHg, p < 00,1). HR as a whole was not significantly different in both age groups, although compared with women of childbearing age in individuals menopause tachycardia was detected significantly higher.

Conclusions:

Despite the fact that the trend towards androgenization 2 times more frequently detected in young women with СHD with preserved cycle compared with patients in menopause, indicators of BP and HR prevailed among women in menopause.

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