PS 08-75 THE RELATIONSHIP BETWEEN SENESCENT T CELL FRACTION AND NONDIPPING IN PATIENTS WITH HYPERTENSION

    loading  Checking for direct PDF access through Ovid

Abstract

Objective:

Recently we demonstrated an increased fractions of senescent CD8+CD57+ T cell in human hypertension. In the current study, we aimed to investigate whether T-cell-senescence is related to the parameters of 24 hour ambulatory blood pressure monitoring (APBM).

Design and Method:

Four hundred and twenty-nine consecutive hypertensive patients with chronic kidney disease who registered in Cardiovascular and Metabolic Disease Etiology Research Center - High Risk Cohort (CMERC-HI, NCT02003781) were enrolled. All subjects underwent 24 hour ABPM.

Results:

There were 234 dipper (60.0 ± 10.7 years, male 67.1%) and 195 nondipper (62.2 ± 10.0 years, male 55.9%) hypertensive patients. The CD8+CD57+ T cell fraction was significantly higher in nondippers compared to dippers (52.7 ± 17.2% vs. 47.7 ± 18.0%, p = 0.025) in men, not in women (p = 0.710). In male subjects, correlation analysis showed that the frequency of CD8+CD57+ T cells was positively related with nocturnal systolic blood pressure (r = 0.162, p = 0.008) and inversely related with systolic blood pressure fall at night (r = -0.130, p = 0.034). Logistic regression analysis revealed that the frequency of CD8+CD57+ T cells is an independent determinant for nondipping hypertension in men (odds ratio 2.69, 95% CI 1.05–6.91, p = 0.040) after adjusting age, body mass index, systolic blood pressure, serum creatinine and C-reactive protein level.

Conclusions:

We showed that the senescent CD8+CD57+ T cell fraction was an independent predictor of nondipping hypertension in men. The mechanism by which T-cell-senescence contributes to a nondipping pattern in human hypertension requires further investigation.

Related Topics

    loading  Loading Related Articles