PS 08-82 CIRCULATING miR-92a EXPRESSION LEVEL IN PATIENTS WITH ESSENTIAL HYPERTENSION: A POTENTIAL MARKER OF ATHEROSCLEROSIS

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Abstract

Objective:

MicroRNA (miR)-92a has been reported to participate in inflammatory reactions and atherosclerosis. The aim is to evaluate the relationship of miR-92a with carotid artery atherosclerosis in hypertension patients.

Design and Method:

A retrospective cohort study of all the patients underwent B-mode ultrasonographic measurement of carotid intima-media thickness(CIMT) and ambulatory blood pressure monitoring. The miR-92a correlation between blood pressure parameters and CIMT were assessed using the Spearman correlation coefficient. The receiver operating characteristic (ROC) curve test was used to evaluate diagnostic performance.

Results:

We recruited 190 participants including 120 hypertension patients (60 men and 60 women; mean age, 50.79 ± 5.35 years) and 70 healthy volunteers (41 men and 29 women, mean age 50.61 ± 5.85years). Baseline data from our patients and controls are presented in (Table 1). We observed higher expression level of miR-92a (31.43 ± 3.51vs25.47 ± 2.86; p < 0.001) in hypertensive patients compared with healthy control individuals. All the 190 participants, we found 53 iCIMT patients (28 men and 25women; mean age, 51.02 ± 4.73 years) and 137 nCIMT(73 men and 64 women, mean age50.61 ± 5.82years). We observed higher expression level of miR-92a (32.37 ± 3.54vs 28.02 ± 4.05; p < 0.001) in iCIMT group compared with nCIMT group. MiR-92a expression level showed significant positive correlation with 24h mean SBP (r = 0.698, p < 0.001), 24h mean DBP (r = 0.496, p < 0.001), 24h Daytime SBP (r = 0.685, p < 0.001), 24h Daytime DBP (r = 0.512, p < 0.001), 24h Nighttime SBP (r = 0.591, p < 0.001), 24h Nighttime DBP (r = 0.412, p < 0.001) and CIMT (r = 0.701, p < 0.001), respectively. miR-92a yielded an AUC of 0.786 (95%CI:0.714,0.859; p < 0.001) (Figure 1D).

Conclusions:

Our study showed that miR-92a expression level was associated positively with 24h ambulatory blood pressure parameters, as well as CIMT, indicating that miR-92a may be a potential non-invasive marker of TOD in hypertensive patients.

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