PS 09-18 THE HYPERURICEMIA PROPORTION IN ESSENTIAL HYPERTENSION POPULATION OF ACEHNESE AT ACEH UTARA DISTRICT

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Abstract

Objective:

To assess the role of serum uric acid (SUA) level and hyperuricemia (HU) in essential hypertension population of Acehnese at Aceh Utara district and to evaluate correlations between SUA level and systolic/diastolic blood pressure (SBP/DBP), creatinine and estimated glomerular filtration rate (eGFR).

Design and Method:

Analytical observational study using cross-sectional approach using consecutive sampling. p value <0.05 was statistically significant.

Results:

The mean of SUA level in both men and women were higher significantly in the EH group (7.71 ± 0.74 mg/dl and 6.85 ± 0.67 mg/dl, respectively) than the NT group (5.79 ± 0.94 mg/dl and 4.6 ± 1.04 mg/dl respectively, p = 0.0001). The HU proportion in the EH group were also higher significantly than the NT group (87.2% and 12.8% respectively, p = 0.0001). The EH patient had 5.4 times higher risk to experience HU than the NT subject (OR = 5.4, 95% CI = 2.52–11.54, p = 0.0001). The mean of SUA level were higher significantly as level of SBP increased in men (p = 0.016). The mean of SUA level were higher significantly as level of DBP increased in both men and women (p = 0.0001 and p = 0.007, respectively). The HU proportion were also higher significantly as level of DBP increased (p = 0.001). There were significant positive correlations between SBP and SUA (r = 0.587; p = 0.0001), DBP and SUA (r = 0.650; p = 0.0001), creatinine and SUA (r = 0.749; p = 0.0001), and significant negative correlation between SUA and eGFR (r = −0.407; p = 0.001).

Conclusions:

The mean of SUA level and HU proportion were significantly higher in EH group. We found significant correlation between EH and HU. The SUA level had significant positive correlations with severity of EH and creatinine, and significant negative correlation with eGFR. The SUA level seemed to be a major risk factor for cardiovascular and renal damage in EH.

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