PS 10-15 TORASEMIDE DUAL BLOCKADE OF PGE SYNTHESIS AND SODIUM CHANNEL IN RENAL FAILURE MODEL

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Abstract

Objective:

Torasemide is a long-acting loop diuretic. Previous study showed that torasemide is associated with low mortality in patients with chronic heart failure (CHF). But it is not known if torasemide is superior in protecting kidney to furosemide. Renal blood flow is precisely controlled to maintain glomerular filtration and fluid and electrolyte homeostasis. Eicosanoids play a critical role in the control of renal hemodynamic as well as inflammations and sodium balance. There are possibilities that torasemide may modulate eicosanoid pathway and be protective in renal function.

Design and Method:

Three-week-old uninephrectomized (UNx) Sprague-Dawley (SD) rats were divided into the following groups: 1) Normal salt diet (0.5% NaCl) as a control; 2) HS (8.0% NaCl) diet alone; 3) HS diet plus treatment with the Torasemide (3mg /(kg day), T3); 4) HS diet plus treatment with the Torasemide (5 mg/(kg day), T5); 5) HS diet plus treatment with the Furosemide (30 mg/(kg day), F30); 6) HS diet plus treatment with the Furosemide (100 mg/(kg day), F100); Rats were treated for 4 weeks, body weight, blood pressure (BP), cardiac and renal function is monitored.

Results:

In current study I used young age of SD rat with high salt loading and uninephrectomized, development of salt-sensitivity hypertension model, after treatment with torasemide decrease body weight, HW/BW, blood pressure (160 mmHg to 120 mmHg), urine protein (125 mg/day to 25 mg/day) level also reverse cardiac left ventricular diastolic function and kidney function. Importantly torasemide could reduce Urinary PGE2 execration level.

Conclusions:

For the first time we showed that Torasemide have strong protect effect on kidney and cardiac function than Furosemide in salt-sensitive hypertension and CKD model.

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