PS 10-21 THE EFFECT OF KI TOLOD (LAURENTIA LONGIFLORA)'S TEA ON THE HYPERCHOLESTROLEMIA RATS

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Abstract

Objective:

Non-Communicable diseases (NCD) are contributed for 38 million deaths based on data of world health organization (WHO) in 2015. WHO also predict that hypercholesterolemia is related to more than half of the incident of coronary heart disease and also more than 17,5 million death every year. The existence of negative effect of the chemical medicine and the opportunity to use herbal medicine as the alternative treatment like using Ki Tolod (Laurentia longiflora), which contain flavonoid, are the reason why this research be held. The aim of this research is to examine the effect of Ki Tolod's tea toward the total cholesterol level of rats.

Design and Method:

This is an experimental research with pre and posttest design. The rats divided into six groups. Three groups of test are the hypercholesterolemia rats (A, B, C) and the other groups are the rats with normal cholesterol which is defined into control (1, 2, 3). Then, they are given the infuse of Ki Tolod with different concentration: 0.25% (A and 1), 0.5% (B and 2), and 1% (C and 3). The total cholesterol level is measured in the 7th and 14th day of infuse treatment.

Results:

The greatest decrease (61 mg/dl) is found in group B (hypercholesterolemia, infuse concentration 0.5%). In general, the test group with hypercholesterolemia had decrease level of total cholesterol. While in control group, the total cholesterol's levels are fluctuate and not show expected result.

Conclusions:

The Ki Tolod's tea decreases the total cholesterol's level in hypercholesterolemia group, but not in control group. Further study use the Ki Tolod's extract are needed to test the active substance toward the hypercholesterolemia and its effective dosage. The toxicology test also needed to undergo to find out the potency of toxic in rats further in human.

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