PS 11-02 THE CORONARY ARTERY CALCIUM SCORE PLAYS AN IMPORTANT ROLE FOR CARDIOVASCULAR RISK STRATIFICATION IN THE STATIN BENEFIT GROUP OF ASYMPTOMATIC INDIVIDUALS

    loading  Checking for direct PDF access through Ovid

Abstract

Objective:

Today's guideline for the assessment of cardiovascular risks and the treatment of blood cholesterol to reduce atherosclerotic cardiovascular diseases (ASCVD) is demonstrated. However, there is a lack of information about available data regarding the relationship between coronary artery calcium score (CACS) using multidetector computed tomography (MDCT) and statin-intensity class of drugs in asymptomatic healthy individuals.

Design and Method:

According to the new guidelines of 2013, all participants (n = 3,817, male: female 2,649: 1,265, mean age: 55 ± 10 years; age 40 to 79 years) in the present study were categorized into three groups by the statin-intensity class of drugs: high-intensity (n = 1,284, 32.8%); moderate-intensity (n = 1,602, 40.9%) and low-intensity statin therapy group (n = 931, 23.8%). We analyzed the relationship between CACS and the statin benefit group. The statin benefit group was defined as individuals who should be considered moderate- and high-intensity statin therapy.

Results:

The ten-year ASCVD (12.6 ± 5.3% vs. 2.9 ± 1.9%, P < 0.001) and CACS (98 ± 270 vs. 3 ± 2, P < 0.001) were significant higher in the high-intensity group than in moderate-intensity statin therapy group. In the high-intensity statin therapy group, age [odds ratio: 1.299 (1.137–1.483), P < 0.001], male gender [odds ratio: 44.252 (1.959–999.784), P = 0.001], and fasting blood glucose [odds ratio: 1.046 (1.007–1.087), P = 0.021] were independent risk factors associated with CACS ≥ 300 by multivariate logistic regression analysis.

Conclusions:

CACS as well as global risk scores plays an important role as a complementary tool for the cardiovascular risk stratification and more specific strategies of statin therapy should be considered in an asymptomatic individual, especially if a high-intensity statin therapy is required.

Related Topics

    loading  Loading Related Articles