PS 11-18 INFECTIOUS-INFLAMMATORY HISTORY AND VASCULAR STIFFNESS IN YOUNG ADULTS

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Abstract

Objective:

To carry out the morphological and functional assessment of vascular status as in patients suffering from CT and people with adverse infectious-inflammatory (II) history.

Design and Method:

It was performed microscopic analysis of blood for the presence of circulating desquamated endothelial cells (DEC) by the method of J. Hlodovec in 20 patients with CT. Age surveyed ranged from 20 to 34 years old. Control group formed of 33 healthy people. Students aged 20 to 24 years carried out comprehensive measurement of elasticity of the vascular wall using diagnostic complex BPLab Vasotens (company “Petr Telegin”, Russia). It was carried out definition of indicators such as pulse wave velocity in the aorta (PWVao); arterial stiffness index (ASI); augmentation index (AIx,%) and others. It was formed two groups on basis of successful history without II diseases (IID) (1gr. – 35persons) and troubled history of IID (2gr. – 20persons.). The results were statistically processed using the software package Biostat.

Results:

Number DEС in patients with CT was found to be on average 7.1 ± 1.3 while in control group the figure was 2.8 ± 0.6. Among students with the presence of adverse history of IID, including CT, PWVao was at 12% and the ASIao at 10% higher compared to the control group. Of all the studied parameters of the vascular status in these groups the most significant changes was AIxao, which difference between the two groups reached significant level to 34%.

Conclusions:

The results indicate involvement of vascular wall in the pathological process during CT and other IID within the systemic response to the presence of focal infection in the body. This is reflected in the increasing number of DEC in blood and indicators of the rigidity of the vascular aortic wall.

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