PS 11-35 I/D GENE ACE POLYMORPHISM AND FEATURES OF CARBOHYDRATE METABOLISM, CYTOKINES ACTIVITY IN PATIENTS WITH ARTERIAL HYPERTENSION

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Abstract

Objective:

Adverse variants of the genotypes of I/D gene angiotensin-converting enzyme (ACE) polymorphism - ID and DD are associated with development of the arterial hypertension (AH). Currently the great interest is attracted to the studying of the general mechanisms of the development of AH and type 2 diabetes mellitus (DM 2 type) and possible protective factors.

Objective:

The purpose - to study the features of carbohydrate metabolism, serum activity of anti-inflammatory interleukin-10 (IL-10) depending on the distribution of I/D gene ACE polymorphism in patients with AH.

Design and Method:

73 patients with AH were examined (divided into 3 groups): the 1st group – 30 patients with ID genotype, the 2nd group – 29 patients with DD genotype, the 3rd group – 14 patients with II genotype. The levels of serum glucose, insulin, HbA1c, IL-10, I/D gene ACE polymorphism were determined, HOMA index was calculated.

Results:

A decrease of IL – 10 level was detected in group1 and 2: (89.3 (88.9–89.7) pg/ml; 88.9 (88.4–89.2) pg/ml, respectively; р < 0.05). Besides, the increase of the indicators of carbohydrate metabolism was found in patients of the group 1 and 2 – level of insulin (11.8 (10.9–12.2) mcU/ml and 13.3 (12.5–14.1) mcU/ml respectively; р < 0.05) and HbA1c (6.6 (6.5–6.8) % and 6.7 (6.5–6.9) % respectively; р < 0.05). During correlation analysis the direct dependence was found between the level of the IL–10 and level of insulin (r = 0.4, p = 0.000), HOMA index (r = 0.5, p = 0.000).

Conclusions:

The obtained data allow to assume, that in patients with AH on the background of prevalence of adverse genotypes ID and DD of ACE I/D gene polymorphism are noted aggravation of carbohydrate metabolism disturbances and decrease of defense mechanisms.

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