PS 11-36 CARDIAC ADAPTATION IN OBESITY

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Abstract

Objective:

The study was determined to study direct effect of various grades of isolated obesity on Echocardiographic indices of systolic and diastolic left ventricular function.

Design and Method:

Study consist of 3 groups. Group 1 (n = 23) consist of normal weight individuals with BMI (18.5–22.9kg/m2), Group 2 (n = 28) of overweight individuals with BMI (23–24.9kg/m2), Group 3 (n = 24) of obese individuals with (BMI > 25kg/m2). Echocardiographic indices of systolic and diastolic functions were obtained and dysfunction was assumed when at least two values differed by >2 SD from normal weight group. Ejection fraction was increased (p = 0.001) in group 2 and group 3. shortening was increased significantly in group 3 (<0.001). Left ventricular dimensions (EDD & ESD) were increased (p < 0.001, 0.002) but relative wall thickness was unchanged in group 2 & 3.

Results:

Systolic dysfunction was not observed in any of the obese patients. The deceleration time was increased (p < 0.01) in overweight and obese subjects compared to normal group individuals. No difference was found between obesity subgroups. Subclinical diastolic dysfunction in the form of reduced E/A ratio and increased deceleration time was more prevalent among obese subjects.

Conclusions:

BMI correlated with significantly with indices of left ventricular diastolic dysfunction was noted in all grades of obesity which correlates with BMI.

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