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To study the Platelet volume indices (PVI) – mean platelet volume (MPV) and Platelet distribution width (PDW) as markers of platelets activation in Sudanese patients with type 2 diabetes mellitus.Descriptive study conducted at Soba University Hospital from March to May 2011. A total of 40 Sudanese patients with type 2 diabetes mellitus and 10 non diabetic individuals as controls were enrolled in this study, including both genders with age group 20–85 years old. Two and half ml of venous blood was collected from all individuals, in EDTA anticoagulant. A blood cell counter sysmex KX -21 was used to measure PVI within two hours after sample collection.All PVI were significantly raised in diabetic patients. Mean MPV 9.97 FL (p = 0.001), and mean PDW 12.54 FL (p = 0.010) compared with the non-diabetic individuals Mean MPV 9.1 FL, and mean PDW 11.89 FL. There were no statistically differences between gender and age groups (MPV p = 0.949, p = 0.415, PDW p = 0.874, p = 0.306 respectively).Larger platelets are haemostatically more active and are risk factor for developing thrombosis and cardiovascular related diseases. PVI are an important, simple, effortless, and cost effective tool that should be used and explored extensively for predicating the possibility of impending acute events in type2 diabetes mellitus patients, especially in countries such as Sudan.