PS 11-38 CENTRAL OBESITY IN PRE AND POST MENOPAUSAL WOMEN: RELATIONSHIP BETWEEN FUNCTIONAL CAPACITY, DYSPNEA, FATIGUE, QUALITY OF LIFE AND COGNITIVE FUNCTION.

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Abstract

Objective:

Central obesity is a well-known risk factor for cardiovascular disease. This study has been planned to evaluate central obesity in pre and post menopausal women and its’ relationship between functional capacity, dyspnea and fatigue, quality of life and cognitive function.

Design and Method:

Nineteen pre and post menopausal women were enrolled in this study. Central obesity, was defined as waist circumference ≥ 88 cm. Participants were categorized by waist circumference (≤ 88, n = 9, mean age 55.7 ± 4.9; >88, n = 10, mean age 49.7 ± 8.8). Functional capacity was measured by six minute walk test (6MWT). Level of dyspnea and fatigue was determined by Borg scale before and after the test. In addition, dyspnea level was assessed with modified Medical Research Council scale (mMRC). Quality of life was evaluated using generic 36-item Short-Form Survey (SF-36). Cognitive function was assessed with the mini mental state examination (MMSE).

Results:

Six minute walk distances were similar between the groups. mMRC score and BORG fatigue score change during 6MWT were significantly higher in large waist circumference than in lower waist circumference. SF36 physical function, role-physical and physical component scores and MMSE score were significantly lower in the large waist circumference compared to the lower waist circumference. Waist circumference was significantly correlated with changes in BORG fatigue and dyspnea scores during 6MWT (respectively: r = 0.60, p = 0.006; = 0.47, p = 0.04), mMRC score (r = 0.53, p = 0.02), SF36 physical function (r = −0.63, p = 0.004), role-physical (r = −0.46, p = 0.04), bodily pain (r = −0.50, p = 0.003) and physical component scores (r = −0.55, p = 0.01) and MMSE score (r = −0.56, p = 0.01).

Conclusions:

In conclusion, in pre and post menopausal women, central obesity defined as increased waist circumference has been found to be associated with increased dyspnea and fatigue with effort, decrease in physical component of quality of life and cognitive functions.

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